D.V. Bulgin¹, V.A. Karabanov², R.V. Karabanov²
¹ Federal Research Institute of Medical Primatology, Sochi, 2019
² "Synthestech", Scientific Research Center, Sochi
The safety and efficiency of long-term taking this vitamin-mineral complex based on iron citrate were explored in laboratory SHK-line mice. It has been proven that iron citrate does not have a toxic (damaging) effect on the internal organs and tissues of mice. The basic cellular parameters of the bone marrow were studied. The effect of iron citrate on the intensity and dynamics of cell populations proliferative activity in all sprouts of the bone marrow hematopoiesis was revealed.
It is known that the main source of stem cells (SC) is bone marrow (BM). The phenomenon of remote control of BM over the processes of tissue and organ regeneration has been scientifically proven, and SC BM are directly involved in these processes.
Bone marrow isthe foundation of stem cells and progenitor cells.
The cellular composition of BM is heterogeneous in origin and morphology; BM cells are represented at different stages of their development, among them are mononuclear BM cells (bone marrow mononuclear cells / BMMNCs).
All BM cells that have one nucleus and do not contain granules in the cytoplasm are commonly referred to the BMMNCs population. Among BMMNCs, there is a big amount of cells - hematopoietic precursors at different stages of maturation, lymphocytes, plasma cells, monocytes.
The BMMNCs fraction is an extensive source of cells that can be used in regenerative medicine and tissue engineering technologies.
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