The Impact of Synthesit on Cognitive Functions

Neurocognitive Effects of Synthesit: Improved Memory and Learning Speed
Wellness

Baiyr Dombaanai1, Roman Karabanov2, Shahbaz Baig3

1. Department of Neurosurgery, Burdenko Neurosurgery Institute: Moscow, RU, Place de Longemalle 1, Genève, 1204, Switzerland;
2. Department of European Studies, SPBGU, Saint-Petersberg, Russia, Place de Longemalle 1, Genève, 1204, Switzerland;
3. Department of Community Medicine, Independence Medical College, 177-P, Jinnah Colony, Faisalabad.

This is one of the first studies on Synthesit, with data processed only 5 years after the experiment was conducted. The experiment was carried out by one of the creators of Synthesit — Roman Karabanov. Video data from this experiment was recovered using modern AI utilities. The data analysis was conducted by an international team led by Shahbaz Baig. The results demonstrated an impressive effect of Synthesit on the cognitive abilities of living organisms, which correlates with numerous consumer testimonials regarding Synthesit.

Methodology

Scientists conducted a six-day experiment on SHK mice, divided into control and experimental groups. The experimental group received a supplement at a dosage of 50 μg/day.

Cognitive functions were assessed using an eight-arm radial maze, where food rewards were placed in four randomly selected arms.

Fig. 1. Diagram of the eight-arm radial maze and experimental stages for assessing cognitivefunctions in mice.


The testing protocol included the following stages: habituation (10 minutes of free exploration without food), training (5-6 minutes to locate all rewards, recording correct and incorrect entries), and immediate testing, which was conducted twice a day for 6 days with a break on the fifth day to assess long-term memory. Between sessions, the maze was cleaned with 70% ethanol to eliminate the influence of olfactory cues. The number of correct/incorrect entries, total completion time, and an integrated memory score (P) were analyzed.

Liver tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Myocardial tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Kidney tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Lung tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

In other words, the researchers first allowed the mice to simply acclimate to the maze, reducing their anxiety. Then, the actual training phase began: the mice searched for a hidden treat, and the researchers carefully monitored their successes and errors. To prevent the mice from following each other's scent trails, the maze was thoroughly wiped down with ethanol after each run.

The testing was intensive, with two sessions per day. A special break on the fifth day helped assess whether the mice had simply memorized the maze for a short period or had genuinely retained the information long-term. Ultimately, the analysis focused not just on speed, but on the quality of memory: how many times a mouse made a mistake before finding the correct path, and how consistently it reproduced the correct route.

Liver tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Myocardial tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Kidney tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Lung tissue of a typical histological structure

(hematoxylin and eosin coloring, x400 scaling)

Results

The results of the eight-arm radial maze testing were impressive across many metrics. The data revealed not just a moderate improvement, but a statistically significant breakthrough in cognitive functions in just 6 days.

1. Training Dynamics

Day 3: The experimental group showed an increase in correct entries up to 4, while the control group remained at 2-4.

Day 6: A statistically significant advantage in memory performance (P = -0.19 vs -0.38 in the control; p < 0.05). This corresponds to a 50% improvement in spatial memory performance.

The training dynamics showed that by the third day, the mice receiving iron were making significantly fewer errors and finding the correct path more often. By the end of the experiment, this resulted in a scientifically proven difference: the memory performance of the group receiving Synthesit improved by 50% compared to the control group.


2. Task completion time

Control group: 18% reduction in task completion time (from 316 to 305 seconds).

Experimental group: 30% reduction in task completion time (from 322 to 295 seconds).

These figures show that the mice receiving Synthesit not only remembered the path better but also found it significantly faster. The experimental group demonstrated a sharp jump in speed – the animals navigated the maze 30% faster. This suggests that Synthesit can improve not only memory but also decision-making speed – the mice processed information more efficiently and acted more confidently.


3. Long term memory retention 

The experimental group retained an advantage after a 5-day break: 

  • an average of 3.2 correct answers compared to 2.8 in the control group. 
  • Spatial memory was retained even after a break in testing.
This data highlights a crucial point: the effect of the supplement wasn't temporary, but rather sustained. Even after a full five-day break, the mice that received Synthesit continued to demonstrate better recall of the correct routes. The difference of 3.2 versus 2.8 correct answers signifies that their brains not only learned but also retained the information. This suggests that Synthesit iron citrate specifically impacted the deep-seated mechanisms of long-term memory formation.


4. Statistical significance 

  • All metrics show a sustained positive trajectory.
  • The differences in the memory metric are statistically significant (p < 0,05).
P < 0,05 value is a commonly accepted standard in scientific research. It means that the probability of obtaining such results by chance is less than 5%. Therefore, the memory improvement in mice receiving iron is not a coincidence or an experimental error; it’s a real, statistically proven effect. It can be confidently stated that Synthesit iron citrate caused a sustained improvement in cognitive functions.


In conclusion, the research conducted strongly suggests that a course of Synthesit, a highly bioavailable form of iron, can be an effective means of supporting and enhancing cognitive function. The findings persuasively indicate a beneficial effect of the supplement on spatial memory, learning rate, and long-term information storage, which is substantiated by objective measurements.

Published in the journal:
seejph.com/index.php/seejph/article/view/6663

Bone marrow of a mouse not taking iron citrate

(hematoxylin and eosin coloring, x400 scaling)

Bone marrow of a mouse taking iron citrate

(hematoxylin and eosin coloring, x400 scaling)
THE CONTROL

A smear imprint of the bone marrow of a mouse not taking iron citrate

(May-Grunwald-Giemsa coloring, cytological micropreparation, scaling x400)
THE EXPERIMENT

A smear imprint of the bone marrow of a mouse taking iron citrate

(May-Grunwald-Giemsa coloring, cytological micropreparation, scaling x400)
THE CONTROL

A smear imprint of the bone marrow of a mouse not taking iron citrate

(May-Grunwald-Giemsa coloring, cytological micropreparation, scaling x1000)
THE EXPERIMENT

A smear imprint of the bone marrow of a mouse taking iron citrate

(May-Grunwald-Giemsa coloring, cytological micropreparation, scaling x1000)
INDICATORS
CONTROL GROUP
EXPERIMENTAL GROUP
Total myelokaryocyte amount (on the thigh),mln
15,0 ± 0,9
*22,2 ± 1,2
Reticular cells
1,3 ± 0,1
*1,5 ± 0,1
Non-deferred blasts(monocular cells)
2,2 ± 0,1
*5,4 ± 0,1
Myeloblasts
2,1 ± 0,1
*3,5 ± 0,1
Myeloid cell mitosis
0,1 ± 0,0
*0,2 ± 0,0
Lymphocytes
16,8 ± 1,8
*22,0 ± 1,1
Megakaryocytes
0,3 ± 0,0
*1,1 ± 0,1
Erythroblasts
0,5 ± 0,1
*1,9 ± 0,1
*statistically significant difference compared with the control group.

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